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Journal Article

Zebrafish gastrulation movements: bridging cell and developmental biology


Heisenberg,  Carl Philipp
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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Heisenberg, C. P., & Tada, M. (2002). Zebrafish gastrulation movements: bridging cell and developmental biology. Seminars in Cell & Developmental Biology, 13(6), 471-479.

Cite as: https://hdl.handle.net/21.11116/0000-0001-13BF-3
During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilobite, exhibit defects in morphogenesis during gastrulation. The identification of the genes mutated in these lines together with the analysis of the mutant phenotypes has provided new insights into the molecular and cellular mechanisms that underlie vertebrate gastrulation movements.