English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Sleep-active neurons: Conserved motors of sleep.

MPS-Authors
/persons/resource/persons14894

Bringmann,  H.
Research Group of Sleep and Waking, MPI for biophysical chemistry, Max Planck Society;

Locator
There are no locators available
Fulltext (public)

2574094.pdf
(Publisher version), 890KB

Supplementary Material (public)
There is no public supplementary material available
Citation

Bringmann, H. (2018). Sleep-active neurons: Conserved motors of sleep. Genetics, 208(4), 1279-1289. doi:10.1534/genetics.117.300521.


Cite as: http://hdl.handle.net/21.11116/0000-0001-1B75-E
Abstract
Sleep is crucial for survival and well-being. This behavioral and physiological state has been studied in all major genetically accessible model animals, including rodents, fish, flies, and worms. Genetic and optogenetic studies have identified several neurons that control sleep, making it now possible to compare circuit mechanisms across species. The "motor" of sleep across animal species is formed by neurons that depolarize at the onset of sleep to actively induce this state by directly inhibiting wakefulness. These sleep-inducing neurons are themselves controlled by inhibitory or activating upstream pathways, which act as the "drivers" of the sleep motor: arousal inhibits "sleep-active" neurons whereas various sleep-promoting "tiredness" pathways converge onto sleep-active neurons to depolarize them. This review provides the first overview of sleep-active neurons across the major model animals. The occurrence of sleep-active neurons and their regulation by upstream pathways in both vertebrate and invertebrate species suggests that these neurons are general and ancient components that evolved early in the history of nervous systems.