Investigating Regional Relationships between Amyloid-Beta and Brain Metabolism 
in Healthy Elderly Controls

Schreiner, SJ; Kirchner, T; Gietl, A; Steininger, SC; Wyss, M; Buck, A; Leh, SE; Nitsch, RM; Prüssmann, KP; Hock, C; Henning, Anke; Unschuld, PG

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Poster

Investigating Regional Relationships between Amyloid-Beta and Brain Metabolism in Healthy Elderly Controls

MPS-Authors

/persons/resource/persons84402

Henning, Anke
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

http://www.content.usz.ch/non_cms/zkf/DOCR/Abstract20Book2013th20Day20of20Clinical20Research20201420USZ.pdf
(Abstract)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Schreiner, S., Kirchner, T., Gietl, A., Steininger, S., Wyss, M., Buck, A., et al. (2014). Investigating Regional Relationships between Amyloid-Beta and Brain Metabolism in Healthy Elderly Controls. Poster presented at 13th Day of Clinical Research, Zürich, Switzerland.

Cite as: https://hdl.handle.net/21.11116/0000-0001-329C-7

Abstract

Introduction: Deposition of amyloid-β (Aβ) in the brain is a hallmark of Alzheimer's disease (AD), but its consequences regarding brain metabolism are largely unknown. Regional Aβ accumulation can be assessed with Pittsburgh compound-B positron-emission-tomography (PiB-PET) and magnetic resonance spectroscopic imaging (MRSI) non-invasively quantifies regional brain metabolite levels. This study aims to investigate potential regional effects of Aβ accumulation on brain metabolite levels in healthy controls and will be extended to clinical cohorts with mild cognitive impairment and AD. Methods: MRSI was performed at high field strength of 7 Tesla to increase signal-to-noise ratio and spatial resolution, and was applied to a pilot-cohort of healthy, cognitively normal elderly adults (n=14). Individual cortical Aβ load was quantified based on PiB-PET late frame signals. Regional correlation of PiB-PET signals with the respective metabolite-levels of MRSI was performed based on tissue-specific probability maps. Results: As this is an on-going study, recruitment of clinical cohorts will continue. The newest results regarding the relationship of individual cortical Aβ load with regional metabolite concentrations will be presented. Conclusion: Investigating the regional association between deposition of Aβ and corresponding brain metabolite levels will allow us to draw conclusions about regional Aβ-associated neuronal stress. This study will characterize the metabolic signature of asymptomatic brain amyloidosis, and will help to evaluate MRSI as a potential AD biomarker.