Towards metabolic profiling of the neurocircuitry of mood: small-voxel, 
non-water-suppressed 1H-MRS in the nucleus accumbens, amygdala and cingulate 
cortex at 3T

Hock, A; Zoelch, N; Scheidegger, M; Herdener, M; Seifritz, E; Henning, Anke

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Towards metabolic profiling of the neurocircuitry of mood: small-voxel, non-water-suppressed 1H-MRS in the nucleus accumbens, amygdala and cingulate cortex at 3T

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Henning, Anke
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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http://www.ismrm.org/14/program_files/TP14.htm
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Citation

Hock, A., Zoelch, N., Scheidegger, M., Herdener, M., Seifritz, E., & Henning, A. (2014). Towards metabolic profiling of the neurocircuitry of mood: small-voxel, non-water-suppressed 1H-MRS in the nucleus accumbens, amygdala and cingulate cortex at 3T. Poster presented at Joint Annual Meeting ISMRM-ESMRMB 2014, Milano, Italy.

Cite as: https://hdl.handle.net/21.11116/0000-0001-32ED-C

Abstract

MRS measurements in small, specific human brain regions with high clinical relevance for neuropsychiatric disorders are executed using non-water suppressed MRS enabling frequency and phase alignment of individual FIDs prior averaging. Results obtained from 16 healthy volunteers from the anterior cingulate cortex, the nucleus accumbens, the amygdala, and the occipital cortex show, that Creatine, N-acetyl-aspartate, glutamate and the combination of Glu and glutamine, choline and myo-inositol could be quantified reliably in group average spectra and by far the most individual data sets. This may promote better understanding of possible dysfunctions of brain metabolism and neurotransmission in neuropsychiatric disorders.