Accuracy and Precision Analysis in Spectral Fitting: A Lesson Learned from 
ProFit

Scheidegger, M; Fuchs, A; Henning, Anke

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Meeting Abstract

Accuracy and Precision Analysis in Spectral Fitting: A Lesson Learned from ProFit

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Henning, Anke
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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http://www.ismrm.org/14/program_files/Session63.htm
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Citation

Scheidegger, M., Fuchs, A., & Henning, A. (2014). Accuracy and Precision Analysis in Spectral Fitting: A Lesson Learned from ProFit. In Joint Annual Meeting ISMRM-ESMRMB 2014.

Cite as: https://hdl.handle.net/21.11116/0000-0001-33E4-4

Abstract

This work demonstrates that both accuracy and precision are important to evaluate for performance validation of spectral fitting packages as demonstrated on the example of ProFit – a spectral fitting package for 2D JPRESS. Strong regularization or tight constraints as implemented in different commercial or freely available spectral fitting routines can lead to small coefficients of variance but strong bias of the quantification results which hinder the detection of naturally occurring variance of metabolite concentrations.