English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

ZEITLUPE in the roots of wild tobacco regulates jasmonate-mediated nicotine biosynthesis and resistance to a generalist herbivore

MPS-Authors
/persons/resource/persons204745

Li,  Ran
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;

/persons/resource/persons140440

Cortés Llorca,  Lucas
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;

/persons/resource/persons4169

Schuman,  Meredith C.
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;

/persons/resource/persons208463

Wang,  Yang
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;

/persons/resource/persons220546

Wang,  Lan Lan
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;

/persons/resource/persons181451

Joo,  Youngsung
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;
IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society;

/persons/resource/persons199274

Wang,  Ming
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;
IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society;

/persons/resource/persons41458

Giddings Vassão,  Daniel
Department of Biochemistry, Prof. J. Gershenzon, MPI for Chemical Ecology, Max Planck Society;

/persons/resource/persons3786

Baldwin,  Ian Thomas
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;

External Ressource
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
Citation

Li, R., Cortés Llorca, L., Schuman, M. C., Wang, Y., Wang, L. L., Joo, Y., et al. (2018). ZEITLUPE in the roots of wild tobacco regulates jasmonate-mediated nicotine biosynthesis and resistance to a generalist herbivore. Plant Physiology, 177(2), 833-846. doi:10.1104/pp.18.00315.


Cite as: http://hdl.handle.net/21.11116/0000-0001-3E77-5
Abstract
The jasmonate (JA) phytohormone signaling system is an important mediator of plant defense against herbivores. Plants deficient in JA signaling are more susceptible to herbivory as a result of deficiencies in defensive trait expression. Recent studies have implicated the circadian clock in regulating JA-mediated defenses, but the molecular mechanisms linking the clock to JA signaling are unclear. Here we report that wild tobacco (Nicotiana attenuata) plants rendered deficient in the clock component ZEITLUPE (ZTL) by RNA interference (RNAi) have attenuated resistance to the generalist herbivore Spodoptera littoralis. This effect can be attributed in part to reduced concentrations of nicotine, an abundant JA-regulated toxin produced in N. attenuata roots and transported to shoots. RNAi targeting ZTL dramatically affects the root circadian clock and reduces the expression of nicotine biosynthetic genes. Protein-protein interaction experiments demonstrate that ZTL regulates JA signaling by directly interacting with JAZ proteins in a COI1- and JA-Ile-independent manner, thereby regulating a JAZ-MYC2 module that is required for nicotine biosynthesis. Our study reveals new functions for ZTL and proposes a mechanism by which a clock component directly influences JA signaling to regulate plant defense against herbivory.