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Journal Article

ZEITLUPE in the roots of wild tobacco regulates jasmonate-mediated nicotine biosynthesis and resistance to a generalist herbivore

MPS-Authors
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Li,  Ran
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;

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Cortés Llorca,  Lucas
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;

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Schuman,  Meredith C.
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;

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Wang,  Yang
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;

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Wang,  Lan Lan
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;

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Joo,  Youngsung
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;
IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society;

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Wang,  Ming
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;
IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society;

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Giddings Vassão,  Daniel
Department of Biochemistry, Prof. J. Gershenzon, MPI for Chemical Ecology, Max Planck Society;

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Baldwin,  Ian Thomas
Department of Molecular Ecology, Prof. I. T. Baldwin, MPI for Chemical Ecology, Max Planck Society;

External Resource

http://dx.doi.org/10.1104/pp.18.00315
(Publisher version)

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Citation

Li, R., Cortés Llorca, L., Schuman, M. C., Wang, Y., Wang, L. L., Joo, Y., et al. (2018). ZEITLUPE in the roots of wild tobacco regulates jasmonate-mediated nicotine biosynthesis and resistance to a generalist herbivore. Plant Physiology, 177(2), 833-846. doi:10.1104/pp.18.00315.


Cite as: https://hdl.handle.net/21.11116/0000-0001-3E77-5
Abstract
The jasmonate (JA) phytohormone signaling system is an important mediator of plant defense against herbivores. Plants deficient in JA signaling are more susceptible to herbivory as a result of deficiencies in defensive trait expression. Recent studies have implicated the circadian clock in regulating JA-mediated defenses, but the molecular mechanisms linking the clock to JA signaling are unclear. Here we report that wild tobacco (Nicotiana attenuata) plants rendered deficient in the clock component ZEITLUPE (ZTL) by RNA interference (RNAi) have attenuated resistance to the generalist herbivore Spodoptera littoralis. This effect can be attributed in part to reduced concentrations of nicotine, an abundant JA-regulated toxin produced in N. attenuata roots and transported to shoots. RNAi targeting ZTL dramatically affects the root circadian clock and reduces the expression of nicotine biosynthetic genes. Protein-protein interaction experiments demonstrate that ZTL regulates JA signaling by directly interacting with JAZ proteins in a COI1- and JA-Ile-independent manner, thereby regulating a JAZ-MYC2 module that is required for nicotine biosynthesis. Our study reveals new functions for ZTL and proposes a mechanism by which a clock component directly influences JA signaling to regulate plant defense against herbivory.