English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Why do proteases mess up with antigen presentation by re-shuffling antigen sequences?

MPS-Authors
/persons/resource/persons208298

Liepe,  J.
Research Group of Quantitative and System Biology, MPI for Biophysical Chemistry, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)

2586018.pdf
(Publisher version), 2MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Liepe, J., Ovaa, H., & Mishto, M. (2018). Why do proteases mess up with antigen presentation by re-shuffling antigen sequences? Current Opinion in Immunology, 52, 81-86. doi:10.1016/j.coi.2018.04.016.


Cite as: http://hdl.handle.net/21.11116/0000-0001-44ED-8
Abstract
The sequence of a large number of MHC-presented epitopes is not present as such in the original antigen because it has been re-shuffled by the proteasome or other proteases. Why do proteases throw a spanner in the works of our model of antigen tagging and immune recognition? We describe in this review what we know about the immunological relevance of post-translationally spliced epitopes and why proteases seem to have a second (dark) personality, which is keen to create new peptide bonds.