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Exchange-dependent relaxation in the rotating frame for slow and intermediate exchange: Modeling off-resonant spin-lock and chemical exchange saturation transfer

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Zaiss, M., Goerke, S., Xu, J., Khan, I., Singer, R., Gore, J., et al. (2013). Exchange-dependent relaxation in the rotating frame for slow and intermediate exchange: Modeling off-resonant spin-lock and chemical exchange saturation transfer. In 16. Jahrestagung Deutschen Sektion der ISMRM e.V. (DS ISMRM 2013) (pp. 35-39).


Cite as: http://hdl.handle.net/21.11116/0000-0001-4A7D-1
Abstract
By eigenspace analysis of the Bloch-McConnell equation we found a general signal equation for chemical exchange saturation transfer imaging experiments. The solution is easy extendable to the multi-pool situation in vivo including a broad semisolid MT pool. Investigation of the theory leads to an interesting and easy to employ result: effects in the Z-spectrum add up reciprocally! Therefore, difference image methods lead to a clean CEST contrast if images are first inverted and then subtracted. This allowed for clean in-vivo CEST evaluation in the case of acute stroke.