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Exchange-dependent relaxation in the rotating frame for slow and intermediate exchange: Modeling off-resonant spin-lock and chemical exchange saturation transfer

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https://frl.publisso.de/resource/frl:5372207-1/data
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Citation

Zaiss, M., Goerke, S., Xu, J., Khan, I., Singer, R., Gore, J., et al. (2013). Exchange-dependent relaxation in the rotating frame for slow and intermediate exchange: Modeling off-resonant spin-lock and chemical exchange saturation transfer. In 16. Jahrestagung Deutschen Sektion der ISMRM e.V. (DS ISMRM 2013) (pp. 35-39).


Cite as: https://hdl.handle.net/21.11116/0000-0001-4A7D-1
Abstract
By eigenspace analysis of the
Bloch-McConnell equation we found a general
signal equation for chemical exchange
saturation transfer imaging experiments. The
solution is easy extendable to the multi-pool
situation in vivo including a broad semisolid MT
pool.
Investigation of the theory leads to an
interesting and easy to employ result: effects in the
Z-spectrum add up reciprocally! Therefore,
difference image methods lead to a clean CEST
contrast if images are first inverted and then subtracted. This allowed for clean in-vivo CEST evaluation in the case of acute stroke.