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Experimental investigation of the relation between gradient echo BOLD fMRI contrast and underlying susceptibility changes at 7T

MPG-Autoren
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Balla,  DZ
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Hagberg,  GE
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Scheffler,  K
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Balla, D., Sanchez Panchuelo, R., Wharton, S., Hagberg, G., Scheffler, K., Francis, S., et al. (2013). Experimental investigation of the relation between gradient echo BOLD fMRI contrast and underlying susceptibility changes at 7T. In 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013).


Zitierlink: https://hdl.handle.net/21.11116/0000-0001-4F52-B
Zusammenfassung
Gradient echo BOLD fMRI contrast was compared to the underlying local susceptibility changes, calculated from the same time-series using functional quantitative susceptibility mapping (fQSM). Comparing voxels coincidentally activated in both fQSM and GE-fMRI, differences were found between motor, visual and somatosensory paradigms in the respective brain areas. In most of these common voxels the signs of susceptibility and magnitude change were opposite confirming expectations. Yet, in a significant number of voxels the signs matched, suggesting strong non-local contributions. Experiments with the motor paradigm showed positive susceptibility shifts and magnitude signal changes in deep cortical layers.