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Meta-populational demes constitute a reservoir for large MHC allele diversity in wild house mice (Mus musculus)

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Linnenbrink,  Miriam
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Teschke,  Meike
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Montero,  Inka
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Vallier,  Marie
Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Tautz,  Diethard
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Citation

Linnenbrink, M., Teschke, M., Montero, I., Vallier, M., & Tautz, D. (2018). Meta-populational demes constitute a reservoir for large MHC allele diversity in wild house mice (Mus musculus). Frontiers in Zoology, 15: 15. doi:10.1186/s12983-018-0266-9.


Cite as: http://hdl.handle.net/21.11116/0000-0001-553F-A
Abstract
The MHC class I and II loci mediate the adaptive immune response and belong to the most polymorphic loci in vertebrate genomes. In fact, the number of different alleles in a given species is often so large that it remains a challenge to provide an evolutionary model that can fully account for this.