Probing 7 Tesla High Field Strength Magnetic Resonance Imaging (MRI) as 
Potential Biomarker for Beta-Amyloid Associated Neuronal Stress

Unschuld, PG; Gietl, A; Kirchner, T; Wyss, M; Buck, A; Leh-Seal, S; Nitsch, RM; Henning, A; Pruessmann, K; Hock, C

doi:10.1016/S0006-3223(13)00287-4

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Probing 7 Tesla High Field Strength Magnetic Resonance Imaging (MRI) as Potential Biomarker for Beta-Amyloid Associated Neuronal Stress

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https://www.sciencedirect.com/science/article/pii/S0006322313002874
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Unschuld, P., Gietl, A., Kirchner, T., Wyss, M., Buck, A., Leh-Seal, S., et al. (2013). Probing 7 Tesla High Field Strength Magnetic Resonance Imaging (MRI) as Potential Biomarker for Beta-Amyloid Associated Neuronal Stress. Poster presented at 68th Annual Scientific Meeting of the Society of Biological Psychiatry, San Francisco, CA, USA.

Cite as: https://hdl.handle.net/21.11116/0000-0001-556C-7

Abstract

Background: Deposition of beta-amyloid (Aβ) peptide in the brain is a pathological hallmark of Alzheimer’s disease (AD) and the regional extent of Aβ accumulation can be assessed non invasively by Pittsburgh Compound-B amyloid imaging (PiB-PET). MRI at high field-strength of 7 Tesla (7T) provides significantly increased signal-to-noise-ratios and thus may provide the specificity needed to identify signatures of potential Aβ associated regional neurotoxicity. A particular goal of this project is to assess regional effects of Aβ in asymptomatic individuals at increased risk for AD. Methods: A study population consisting of asymptomatic individuals at increased risk for AD (age > 60 years) and individuals with mild cognitive impairment (MCI) has been administered PiB-PET and a neuropsychological battery testing individual cognitive performance. Based on regional intensity of the PiB-PET late frame signals, subgroups were formed reflecting the individual level of regional Aβ-deposition. In addition 7T MRI sequences are used to acquire functional and metabolic correlates of neuronal stress, including BOLD resting state functional MRI (rs-fMRI), Magnetic-Resonance-Spectroscopic-Imaging (MRSI), gradient echo susceptibility weighted imaging (T2*) and structural MRI (MPRAGE). Regional PiB-intensity is tested for correlations with MRI-contrasts and also for relationships with individual cognitive performance-levels. Results: Preliminary data will be presented, including first results indicating effects on functional network integrity (rs-fMRI), regional iron deposition and calcification (T2*), as well as concentrations of brain metabolites (MRSI). Conclusions: This study will provide evidence regarding the applicability of MRI at 7T to identify amyloid deposition associated neuronal stress and potentially increased risk for AD.