MTRRex: a spillover correction for pulsed steady-state CEST

Zaiss, M; Bachert, P

doi:10.1002/cmmi.1522

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MTRRex: a spillover correction for pulsed steady-state CEST

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http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1522/full
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Zaiss, M., & Bachert, P. (2012). MTRRex: a spillover correction for pulsed steady-state CEST. Poster presented at 3rd International Workshop on Chemical Exchange Saturation Transfer Imaging (OctoberCEST 2012), Annapolis, MD, USA.

Cite as: https://hdl.handle.net/21.11116/0000-0001-556E-5

Abstract

Introduction: Studying endogenous chemical exchange saturation transfer (CEST) effects always requires the handling of competing effects such as direct water saturation and macromolecular MT. We want to compare different spillover and macroMT corrections for pulsed CEST experiments with a new normalization MTRRex. For verification, amine proton exchange of creatine in solutions with different agar concentrations is probed.
Theory: As spin-lock theory can be applied to CEST [1],[2], we employ the formula for normalized steady-state magnetization after irradiation at label or reference scan:.