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Meeting Abstract

Amide proton chemical exchange saturation transfer at 9.4 T

MPS-Authors
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Mirkes,  C
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84213

Shajan,  G
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons83973

Hoffmann,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84187

Scheffler,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1522/epdf
(Publisher version)

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Citation

Mirkes, C., Shajan, G., Hoffmann, J., & Scheffler, K. (2013). Amide proton chemical exchange saturation transfer at 9.4 T. Contrast Media & Molecular Imaging, 8(3), 311-312.


Cite as: https://hdl.handle.net/21.11116/0000-0001-5570-1
Abstract
The backbone amide groups in peptides and proteins [1] are one of many endogenous compounds able to exhibit a chemical exchange saturation transfer (CEST) effect by exchanging protons with water molecules. The resonance frequency of the amide protons is situated at 3.6 ppm from the water resonance frequency.
Unfortunately, the quantification of the amide proton transfer (APT) effect using a standard asymmetry analysis
approach is hindered by the nuclear Overhauser effect (NOE) at upfield frequencies (e.g. -3.6 ppm). Very recently [2] it has been shown that in rat brain the APT effect and the NOE can be directly discriminated at ultrahigh magnetic field due to the concomitant wide spectral separation. In this initial work we demonstrate that it is possible to acquire amide proton CEST spectra in the human brain at 9.4 T.