Extended metabolite profile of the human spinal cord

Hock, A; Wilm, BJ; MacMillan, EL; Kreis, R; Kollias, SS; Boesiger, P; Henning, A

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Extended metabolite profile of the human spinal cord

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Henning, A
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://www.ismrm.org/13/tp15.htm
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Zitation

Hock, A., Wilm, B., MacMillan, E., Kreis, R., Kollias, S., Boesiger, P., et al. (2013). Extended metabolite profile of the human spinal cord. Poster presented at 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT, USA.

Zitierlink: https://hdl.handle.net/21.11116/0000-0001-5582-C

Zusammenfassung

Clinical magnetic resonance spectroscopy is rarely applied in the spinal cord due to technical challenges leading to a low spectral quality and thus to a limited number of reliable detectable metabolites. In order to extend the metabolite profile an increase of the spectral quality is necessary, which could be achieved by both: averaging a high number of FIDs and by using a dedicated neck coil. Besides N-acetyl aspartate, creatine, choline and myo-inositol a reliable detection of scyllo-inositol and glutamine/glutamate was possible. Increased myo-inositol/creatine and scyllo-inositol/creatine ratios compared to brain estimates can be observed in the spinal cord.