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Effects of an Antidepressant Dose of Ketamine on Prefrontal Aspartate, Glutamine and Gaba Levels in Healthy Subjects: Assessing the Post-Infusion Interval with 1H-MRS

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Henning,  A
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Scheidegger, M., Fuchs, A., Lehmann, M., Grimm, S., Boeker, H., Seifritz, E., et al. (2013). Effects of an Antidepressant Dose of Ketamine on Prefrontal Aspartate, Glutamine and Gaba Levels in Healthy Subjects: Assessing the Post-Infusion Interval with 1H-MRS. In 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013).


Cite as: http://hdl.handle.net/21.11116/0000-0001-5598-4
Abstract
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at subanaesthetic doses, thus providing a valuable research tool for the investigation of the neurobiology of major depressive disorder (MDD). This double-blind, randomized, placebo-controlled 1H-MRS study in 13 healthy subjects reveals the neuropharmacological effects of a single intravenous subanaesthetic ketamine infusion on prefrontal aspartate, glutamine and GABA levels in the 3-4 hour post-infusion interval. Our findings are in line with a shift in the excitatory-inhibitory balance following ketamine administration that may play an important role in restoring parts of the disrupted neurometabolic homeostasis in MDD patients.