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Journal Article

Micromotors powered by enzyme catalysis


Golestanian,  R.
Department of Living Matter Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Dey, K. K., Zhao, X., Tansi, B. M., Méndez-Ortiz, J. W., Córdova-Figueroa, U. M., Golestanian, R., et al. (2015). Micromotors powered by enzyme catalysis. Nano Letters, 15(12), 8311-8315. doi:10.1021/acs.nanolett.5b03935.

Cite as: http://hdl.handle.net/21.11116/0000-0001-A796-9
Active biocompatible systems are of great current interest for their possible applications in drug or antidote delivery at specific locations. Herein, we report the synthesis and study of self-propelled microparticles powered by enzymatic reactions and their directed movement in substrate concentration gradient. Polystyrene microparticles were functionalized with the enzymes urease and catalase using a biotin-streptavidin linkage procedure. The motion of the enzyme-coated particles was studied in the presence of the respective substrates, using optical microscopy and dynamic light scattering analysis. The diffusion of the particles was found to increase in a substrate concentration dependent manner. The directed chemotactic movement of these enzyme-powered motors up the substrate gradient was studied using three-inlet microfluidic channel architecture. © 2015 American Chemical Society.