Synucleins Have Multiple Effects on Presynaptic Architecture

Vargas, Karina J.; Schrod, Nikolas; Davis, Taylor; Fernandez-Busnadiego, Ruben; Taguchi, Y. V.; Laugks, Ulrike; Lucic, Vladan; Chandra, S. S.

doi:10.1016/j.celrep.2016.12.023

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Synucleins Have Multiple Effects on Presynaptic Architecture

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Schrod, Nikolas
Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Laugks, Ulrike
Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Lucic, Vladan
Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Vargas, K. J., Schrod, N., Davis, T., Fernandez-Busnadiego, R., Taguchi, Y. V., Laugks, U., et al. (2017). Synucleins Have Multiple Effects on Presynaptic Architecture. Cell Reports, 18(1), 161-173. doi:10.1016/j.celrep.2016.12.023.

Cite as: https://hdl.handle.net/21.11116/0000-0001-64A1-8

Abstract

Synucleins ( a , b , g -synuclein) are abundant presynaptic proteins, with a -synuclein linked to the pathogenesis of Parkinson’s disease. Vargas et al. investigate the effects of deleting synucleins and overexpressing mutated a -synuclein on synapse architecture using electron microscopy. They find that synucleins regulate presynaptic terminal size and synaptic vesicle distribution.