English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells

MPS-Authors
/persons/resource/persons192484

Riesenberg,  Stephan
The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society;
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

/persons/resource/persons72834

Maricic,  Tomislav
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)

Riesenberg_Targeted_NatComm_2018.pdf
(Publisher version), 2MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Riesenberg, S., & Maricic, T. (2018). Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells. Nature Communications, 9: 2164. doi:10.1038/s41467-018-04609-7.


Cite as: http://hdl.handle.net/21.11116/0000-0001-6A92-3
Abstract
Small molecule inhibitors can influence the choice of repair pathways, enhancing nucleotide substitution and gene integration in CRISPR-mediated genome editing. Here the authors introduce CRISPY, a mix of small molecules that can enhance precise editing with Cpf1 and Cas9D10A in hiPSCs.