Functional topography of the human entorhinal cortex

Navarro Schröder , Tobias; Haak, Koen V; Zaragoza Jimenez, Nestor I; Beckmann, Christian F; Doeller, Christian F.

doi:10.7554/eLife.06738

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Functional topography of the human entorhinal cortex

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Navarro Schröder, T., Haak, K. V., Zaragoza Jimenez, N. I., Beckmann, C. F., & Doeller, C. F. (2015). Functional topography of the human entorhinal cortex. eLife, 4: e06738. doi:10.7554/eLife.06738.

Cite as: https://hdl.handle.net/21.11116/0000-0001-709F-E

Abstract

Despite extensive research on the role of the rodent medial and lateral entorhinal cortex (MEC/LEC) in spatial navigation, memory and related disease, their human homologues remain elusive. Here, we combine high-field functional magnetic resonance imaging at 7 T with novel data-driven and model-based analyses to identify corresponding subregions in humans based on the well-known global connectivity fingerprints in rodents and sensitivity to spatial and non-spatial information. We provide evidence for a functional division primarily along the anteroposterior axis. Localising the human homologue of the rodent MEC and LEC has important implications for translating studies on the hippocampo-entorhinal memory system from rodents to humans.