English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Intrahypophyseal Immune-Endocrine Interactions: Endocrine Integration of the Inflammatory Inputs

MPS-Authors
/persons/resource/persons80491

Renner,  U.
RG Günter Stalla, Clinical Neuroendocrinology, Clinical Research, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons110919

Lucia,  K.
RG Clinical Neuroendocrinology, Clinical Research, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80539

Stalla,  G. K.
RG Clinical Neuroendocrinology, Clinical Research, Max Planck Institute of Psychiatry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Renner, U., Sapochnik, M., Lucia, K., Stalla, G. K., & Arzt, E. (2017). Intrahypophyseal Immune-Endocrine Interactions: Endocrine Integration of the Inflammatory Inputs. ENDOCRINE IMMUNOLOGY, 37-47. doi:10.1159/000452904.


Cite as: https://hdl.handle.net/21.11116/0000-0001-BE19-E
Abstract
Endotoxin (lipopolysaccharide, LPS) of gram-negative bacteria has been recognized for more than 40 years as a modulator of anterior pituitary hormone production. The action of LPS was thought to be predominantly mediated through LPS-stimulated immune cell-derived cytokines, and is part of the concept of immune-endocrine crosstalk, which regulates bidirectional adaptive processes between the endocrine and immune systems during inflammatory or infectious processes. With the detection of innate immune system components in the normal and tumoral pituitary, including the Toll-like receptor 4, the target of LPS, it has become evident that LPS can directly modify the physiology and pathophysiology of the anterior pituitary. LPS-induced intrapituitary mechanisms involve the stimulation of intrapituitary cytokines, and also directly act on hormone synthesis, growth, and apoptosis of endocrine cells. This review focuses on the effects of LPS on pituitary physiology, its interaction with pro-and anti-inflammatory factors, and the molecular mechanisms involved in these processes. (C) 2017 S. Karger AG, Basel