Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual 
navigation task

Schuck, Nicolas W.; Doeller, Christian F.; Schjeide, Brit‐Maren M.; Schröder, Julia; Frensch , Peter A.; Bertram, Lars; Li, Shu‐Chen

doi:10.1002/hipo.22148

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual navigation task

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

schuck-hpc-2013-Aging and KIBRA:WWC1 Genotype.pdf
(Any fulltext), 498KB

Supplementary Material (public)

There is no public supplementary material available

Citation

Schuck, N. W., Doeller, C. F., Schjeide, B. M., Schröder, J., Frensch, P. A., Bertram, L., et al. (2013). Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual navigation task. Hippocampus, 23(10), 919-930. doi:10.1002/hipo.22148.

Cite as: https://hdl.handle.net/21.11116/0000-0001-716B-8

Abstract

Spatial navigation relies on multiple mnemonic mechanisms and previous work in younger adults has described two separate types of spatial memory. One type uses directional as well as boundary‐related information for spatial memory and mainly implicates the hippocampal formation. The other type has been linked to directional and landmark‐related information and primarily involves the striatum. Using a virtual reality navigation paradigm, we studied the impacts of aging and a single nucleotide polymorphism (SNP rs17070145) of the KIBRA gene (official name: WWC1) on these memory forms. Our data showed that older adult's spatial learning was preferentially related to processing of landmark information, whereas processing of boundary information played a more prominent role in younger adults. Moreover, among older adults T‐allele carriers of the examined KIBRA polymorphism showed better spatial learning compared to C homozygotes. Together these findings provide the first evidence for an effect of the KIBRA rs17070145 polymorphism on spatial memory in humans and age differences in the reliance on landmark and boundary‐related spatial information.