English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Interspike Interval Analysis and Spikelets in Presubicular Head-Direction Cells

MPS-Authors
There are no MPG-Authors available
External Ressource

Link
(Any fulltext)

Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Coletta, S., Zeraati, R., Nasr, K., Preston-Ferrer, P., & Burgalossi, A. (2018). Interspike Interval Analysis and Spikelets in Presubicular Head-Direction Cells. Journal of Neurophysiology, 120(2), 564-575. doi:10.1152/jn.00019.2018.


Cite as: http://hdl.handle.net/21.11116/0000-0001-7CB1-C
Abstract
Head direction (HD) neurons are thought to provide the mammalian brain with an internal sense of direction. These cells - which selectively increase their firing when the animal's head points in a specific direction - use the spike rate to encode HD with a high signal-to-noise ratio. In the present work, we analyzed spike train features of presubicular HD cells recorded juxtacellularly in passively-rotated rats. We found that HD neurons could be classified into two groups based on their propensity to fire spikes at short interspike intervals. 'Bursty' neurons displayed distinct spike waveforms and were weakly but significantly more modulated by HD compared to 'non-bursty' cells. In a subset of HD neurons, we observed the occurrence of spikelets - small amplitude 'spike-like' events - whose HD tuning was highly correlated to that of the co-recorded juxtacellular spikes. Bursty and non-bursty HD cells, as well as spikelets, were also observed in freely-moving animals during natural behavior. We speculate that spike bursts and spikelets might contribute to PreS HD coding by enhancing its accuracy and transmission reliability to downstream targets.