Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Parahydrogen-based Hyperpolarization for Biomedicine


Buckenmaier,  K
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Hovener, J., Pravdivtsev, A., Kidd, B., Bowers, C., Glöggler, S., Kovtunov, K., et al. (2018). Parahydrogen-based Hyperpolarization for Biomedicine. Angewandte Chemie: International edition, 57(35), 11140-11162. doi:10.1002/anie.201711842.

Cite as: https://hdl.handle.net/21.11116/0000-0001-7D1C-5
NMR is one of the most versatile and useful physical effects used for human imaging, chemical analysis and the elucidation of molecular structures. Yet, the full potential of NMR is hardly ever used, because only a small fraction of the nuclear spin ensemble is polarized - i.e. aligned with the applied static magnetic field. This fraction is termed nuclear spin polarization P. As a result, no more than a few parts per million of all nuclear spins effectively contribute to the signal in all magnetic fields (B0) available for NMR or MRI today. Because P is approximately linear with B0, a stronger field offers some but limited improvements. Hyperpolarization methods seek other means to increase P and thus the MR signal. A unique source of pure spin order is the spin singlet state of dihydrogen, parahydrogen (pH2), which is inherently stable and long-lived. When brought into contact with another molecule, this "spin order on demand" allows enhancing the NMR signal by several orders of magnitude. In contrast to other methods, this process is very fast (seconds) and can take place in the liquid state. Nuclear spin polarization of the order of unity was demonstrated, manifesting as significant NMR and MRI signal enhancement by several orders of magnitude. Considerable progress was made in the past decade in the area of pH2-based hyperpolarization techniques for biomedical applications. It is the goal of this minireview to provide a comprehensive, selective overview of these developments, covering the areas of spin physics, catalysis, instrumentation, contrast agents' preparation and application.