Functional MRI mapping the optogenetic activation of the lateral hypothalamus 
driven by an MRI-guided robotic arm (MgRA)

Chen, Y; Pais, P; Chen, X; Frosz, M; Yu, X

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Functional MRI mapping the optogenetic activation of the lateral hypothalamus driven by an MRI-guided robotic arm (MgRA)

MPS-Authors

/persons/resource/persons214924

Chen, Y
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons214931

Pais, P
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons214920

Chen, X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133486

Yu, X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://archive.ismrm.org/2018/1107.html
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引用

Chen, Y., Pais, P., Chen, X., Frosz, M., & Yu, X. (2018). Functional MRI mapping the optogenetic activation of the lateral hypothalamus driven by an MRI-guided robotic arm (MgRA). In Joint Annual Meeting ISMRM-ESMRMB 2018.

引用: https://hdl.handle.net/21.11116/0000-0001-7D69-E

要旨

A multiple degree-of-freedom robotic controlling system was developed to guide the fiber optic targeting lateral hypothalamus in the rat brain inside the high field (14.1T) MRI scanner. Optogenetic activation of the LH leads to highly reliable functional fMRI activation patterns in the LH and its projecting regions including LPO, MPA, MPOL and StA across animals. The MgRA provides a MR-compatible brain intervention strategy to target deep brain nuclei for optogenetic activation or calcium recordings with high precision and flexibility.