The Angular Dependence of the Gradient Echo and Spin Echo Bold Signal Induced 
by Cortical Micro- and Macro- Vasculature

Báez-Yáñez, M; Tsai, PS; Kleinfeld, D; Scheffler, K

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The Angular Dependence of the Gradient Echo and Spin Echo Bold Signal Induced by Cortical Micro- and Macro- Vasculature

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Báez-Yáñez, M
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Scheffler, K
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Báez-Yáñez, M., Tsai, P., Kleinfeld, D., & Scheffler, K. (2018). The Angular Dependence of the Gradient Echo and Spin Echo Bold Signal Induced by Cortical Micro- and Macro- Vasculature. Poster presented at Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.

Cite as: https://hdl.handle.net/21.11116/0000-0001-7D6F-8

Abstract

In recent investigations, the angular dependence of the BOLD signal with respect to the main magnetic field has been shown by Monte Carlo simulations and experimental approaches. This orientation dependence is often attributed to the contribution of large vessels (cortical surface and penetrating arteries/veins). However, the ability to resolve cortical layers and columns depends ultimately on the contribution of the MR signal generated by the capillary bed. In this work, we studied the MR signal attenuation generated by a vascular network model that was acquired from the parietal cortex of mice using a two-photon laser imaging techniques. We separately investigated the impact of macrovessels (>5 µm in diameter) and microvessels (< 5 µm in diameter) on the BOLD effect.