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Toward Absolute Quantification Using External Reference Standards at 3T and 9.4T

MPS-Authors
/persons/resource/persons215127

Wright,  AM
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons192740

Nassirpour,  S
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons192839

Chang,  P
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84402

Henning,  A
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Wright, A., Nassirpour, S., Chang, P., & Henning, A. (2018). Toward Absolute Quantification Using External Reference Standards at 3T and 9.4T. Poster presented at Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.


Cite as: http://hdl.handle.net/21.11116/0000-0001-7DD0-8
Abstract
Absolute quantification is a challenge with many paths to reach the final goal of quantifying metabolites in absolute units (e.g. Molarity and molality). Utilizing an external reference standard (ERF) is an attractive method for quantifying in vivo metabolites due to the ability for direct comparison between a known concentration of a metabolite and the in vivo data. A major concern in utilization of an ERF is the differences in coil loading between in vivo and in vitro measurements. To that end, this work describes a method to calibrate and adjust the transmitter voltage in order to maximize signal detection independently of coil load.