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In-vivo and ex-vivo beta-amyloid load detection in Alzheimer’s Disease using R2* and quantitative susceptibility mapping (QSM) at ultra-high magnetic field: comparison to histology

MPS-Authors
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Tuzzi,  E
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Hagberg,  GE
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Balla,  D
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Loureiro,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pohmann,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Scheffler,  K
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Tuzzi, E., Hagberg, G., Balla, D., Loureiro, J., Neumann, M., Laske, C., et al. (2018). In-vivo and ex-vivo beta-amyloid load detection in Alzheimer’s Disease using R2* and quantitative susceptibility mapping (QSM) at ultra-high magnetic field: comparison to histology. Poster presented at 24th European Congress of Radiology (ECR 2018), Wien, Austria.


Cite as: http://hdl.handle.net/21.11116/0000-0001-7E06-C
Abstract
Aims and objectives: Alzheimer’s Disease (AD) is the most common cause of dementia worldwide. So far univocal diagnosis of AD is only achieved by postmortem histology. Beta-Amyloid plaques are known to be classical hallmarks of the post mortem Alzheimer´s Disease brain. In-vivo, Beta-Amyloid deposits are currently detec[...] Methods and materials: Two patients with autosomal dominant AD (female 51y, male 35y) and two age and sex-matched healthy subjects (HS) were scanned at 9.4T using a multi-echo (N=5) 3D-GRE sequence (0.375x0.375x0.8mm3 voxel size, TR=35ms; TE=6 to 30ms in steps of 6ms, TA=9min, FOV=192x174x70.4mm3, matrix size=512x464x88) [...] Results: A variation of 70ms-1ca. in the effective transverse relaxation rate was observed between grey and white matter in AD patient compared to healthy subject (Figure 1). A pattern between grey and white matter, corresponding to paramagnetic effects, was also detected in the susceptibility map (0-0.04 pp[...] Conclusion: Both R2* and QSM methods at ultra-high field hold promise for detecting Beta-Amyloid load within the cortical rim providing a potential means for early diagnosis of AD in-vivo. Optimization of the QSM algorithm would likely increase the power of Beta-Amyloid detection ex-vivo and in-vivo.