Correlation between APT-CEST and 18F-Choline PET in glioma at 3T

Rega, M; Torrealdea, F; Hearle, J; Zaiss, M; Carvalho, A; Asaf, A; Punwani, S; Golay, X; Dickson, J; Shankar, A; Hyare, H

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Meeting Abstract

Correlation between APT-CEST and 18F-Choline PET in glioma at 3T

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Zaiss, M
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Rega, M., Torrealdea, F., Hearle, J., Zaiss, M., Carvalho, A., Asaf, A., et al. (2018). Correlation between APT-CEST and 18F-Choline PET in glioma at 3T. In Joint Annual Meeting ISMRM-ESMRMB 2018.

Cite as: https://hdl.handle.net/21.11116/0000-0001-7E10-0

Abstract

Chemical exchange saturation transfer MRI is emerging as a powerful diagnostic tool and has been shown to correlate with glioma tumour grade and molecular genetics. In this study, we aim to investigate whether APT signal is a non-invasive biomarker of Teenage and Young Adult glioma cell proliferation through correlation with 18F-Cho PET SUV as the gold standard. The strong positive correlation found in APT and 18F-Cho PET SUV indirectly demonstrates that APT SI may be a marker of glioma cell proliferation and further demonstrates the potential of APT in the assessment of glioma burden.