Spinal Cord MRS Biomarkers of Clinical Impairment in Chronic Spinal Cord Injury

Wyss, P; Huber, E; Freund, P; Henning, A

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Meeting Abstract

Spinal Cord MRS Biomarkers of Clinical Impairment in Chronic Spinal Cord Injury

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Wyss, P
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Henning, A
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Wyss, P., Huber, E., Freund, P., & Henning, A. (2018). Spinal Cord MRS Biomarkers of Clinical Impairment in Chronic Spinal Cord Injury. In Joint Annual Meeting ISMRM-ESMRMB 2018.

Cite as: https://hdl.handle.net/21.11116/0000-0001-7E1C-4

Abstract

Remote neurodegenerative changes above the level of injury are present following traumatic spinal cord injury (SCI), resulting in atrophy of the cervical cord of up to 30. This study investigates the underlying biochemical changes at the cellular and molecular level which may subtend the development of atrophy using latest magnetic resonance spectroscopy in the spinal cord in healthy controls and SCI patients. Furthermore, we screen for potential MRS biomarkers investigating the association of biochemical changes and clinical outcome.