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Meeting Abstract

Identify the neurovascular coupling efficacy of long-term depolarization or seizer-like events in the hippocampus with optogenetic single-vessel fMRI

MPG-Autoren
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Chen,  X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Sobczak,  F
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Chen,  Y
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Yu,  X
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://www.ismrm.org/18/ToC.pdf
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Zitation

Chen, X., Sobczak, F., Chen, Y., & Yu, X. (2018). Identify the neurovascular coupling efficacy of long-term depolarization or seizer-like events in the hippocampus with optogenetic single-vessel fMRI. In Joint Annual Meeting ISMRM-ESMRMB 2018.


Zitierlink: https://hdl.handle.net/21.11116/0000-0001-7E29-5
Zusammenfassung
Optogenetic activation can elicit seizure-like events in the hippocampus of anesthetized rats. However, it remains unclear how the hemodynamic signaling responds to the seizure-like events or long-term depolarization in hippocampus. Here, we applied the multi-model fMRI platform to acquire concurrent single-vessel fMRI and calcium signal upon optogenetic stimulation in the hippocampus. The neurovascular coupling coefficient was significantly lower for the long-term depolarization/seizure-like calcium event than that of normally evoked events. The reduced neurovascular coupling efficacy during seizure-like events indicates the lack of sufficient blood supply under high-energy demand of long-term depolarization, and eventually causes tissue damage.