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Comparison of two alternative sequences for human in-vivo brain MR Current Density Imaging (MRCDI)

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Ehses,  P
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Scheffler,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Göksu, C., Hanson, L., Siebner, H., Ehses, P., Scheffler, K., & Thielscher, A. (2018). Comparison of two alternative sequences for human in-vivo brain MR Current Density Imaging (MRCDI). Poster presented at Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.


Cite as: https://hdl.handle.net/21.11116/0000-0001-81F5-8
Abstract
MRCDI is a novel technique, utilizing different phase-sensitive MR methods for non-invasive measurements of weak currents in the human body, which is important in several neuroscience applications. Here, we compare the in-vivo performance of two different MR methods, multi-echo spin echo (MESE) and steady-state free precession free induction decay (SSFP-FID), with single- vs. multi-gradient-echo readouts. We demonstrate that multi-gradient-echo readouts improve both methods. We validate the linear dependence of the measured current-induced magnetic field on the injected current strength for both methods, and propose the more efficient SSFP-FID method as being well suited for highly sensitive single-slice human in-vivo MRCDI.