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Journal Article

Direct UV-induced functionalization of surface hydroxy groups by thiol-ol chemistry


Grunze,  Michael
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Li, L., Li, J., Du, X., Well, A., Grunze, M., Trapp, O., et al. (in press). Direct UV-induced functionalization of surface hydroxy groups by thiol-ol chemistry. Angewandte Chemie, International Edition in English, 53(15), 3835-3839. doi:10.1002/anie.201310692.

Cite as: https://hdl.handle.net/21.11116/0000-0001-8834-B
A novel UV-initiated surface modification method for the direct functionalization of surface hydroxy groups with thiol-containing molecules (termed "thiol-ol" modification) is described. This method is based on the oxidative conjugation of thiols to hydroxy groups. We demonstrate that different thiol-containing molecules, such as fluorophores, thiol-terminated poly(ethylene glycol) (PEG-SH), and a cysteine-containing peptide, can be attached onto the surface of porous poly(2-hydroxyethyl methacrylate-co-ethylene dimethacrylate). Direct functionalization of other hydroxy-group-bearing surfaces, fabrication of micropatterns, and double patterning have been also demonstrated using the thiol-ol method.