Fibroblast adhesion on unidirectional polymeric nanofilms

Christophis, Christof; Sekeroglu, Koray; Demirel, Gokhan; Thome, Isabel; Grunze, Michael; Demirel, Melik C.; Rosenhahn, Axel

doi:10.1116/1.3646093

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Fibroblast adhesion on unidirectional polymeric nanofilms

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Grunze, Michael
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Christophis, C., Sekeroglu, K., Demirel, G., Thome, I., Grunze, M., Demirel, M. C., et al. (2011). Fibroblast adhesion on unidirectional polymeric nanofilms. Biointerphases, 6, 158-163. doi:10.1116/1.3646093.

Cite as: https://hdl.handle.net/21.11116/0000-0001-8C0B-6

Abstract

Nanotextured polymeric surfaces with inclined rods reveal highly anisotropic properties concerning wetting and adhesion. In this work, we report on the interaction of fibroblast cells with these highly anisotropic materials. The authors quantified removal of adherent cells from such surfaces by a laminar flow. The critical shear force needed for cell removal from the surface depends on the inclination direction. Based on electron microscopy cross sections we deduce that interactions of cellular filopodia extending into the nanotextured surface are causing the direction depending removal.