Resistance of polysaccharide coatings to proteins, hematopoietic cells, and 
marine organisms

Cao, Xinyu; Pettit, Michala E.; Conlan, Sheelagh L.; Wagner, Wolfgang; Ho, Anthony D.; Clare, Anthony S.; Callow, James A.; Callow, Maureen E.; Grunze, Michael; Rosenhahn, Axel

doi:10.1021/bm8014208

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Resistance of polysaccharide coatings to proteins, hematopoietic cells, and marine organisms

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Grunze, Michael
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Cao, X., Pettit, M. E., Conlan, S. L., Wagner, W., Ho, A. D., Clare, A. S., et al. (2009). Resistance of polysaccharide coatings to proteins, hematopoietic cells, and marine organisms. Biomacromolecules, 10(4), 907-915. doi:10.1021/bm8014208.

Cite as: https://hdl.handle.net/21.11116/0000-0001-9703-1

Abstract

The interaction of covalently coupled hyaluronic acid, alginic acid, and pectic acid with proteins, cells (hematopoietic KG1a and Jurkat cells), and marine organisms (algal zoospores and barnacle cypris larvae) is compared. In contrast to cells and proteins for which such polysaccharide coatings are known for their antiadhesive properties, marine algal spores and barnacle cyprids were able to colonize the surfaces. Of the three polysaccharides, hyaluronic acid showed the lowest settlement of both Ulva zoopores and barnacles. Photoelectron spectroscopy reveals that the polysaccharide coatings tend to bind bivalent ions, such as calcium, from salt water. Such pretreatment with a high salinity medium significantly changes the protein and hematopoietic cell resistance of the surfaces. Complexation of bivalent ions is therefore considered as one reason for the decreased resistance of polysaccharide coatings when applied in the marine environment.