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Journal Article

The Physics of the Metaphase Spindle

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Oriola,  David
Max Planck Institute for the Physics of Complex Systems, Max Planck Society;

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Brugués,  Jan
Max Planck Institute for the Physics of Complex Systems, Max Planck Society;

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Citation

Oriola, D., Needleman, D. J., & Brugués, J. (2018). The Physics of the Metaphase Spindle. Annual Review of Biophysics, 47, 655-673. doi:10.1146/annurev-biophys-060414-034107.


Cite as: https://hdl.handle.net/21.11116/0000-0001-B8B9-F
Abstract
The assembly of the mitotic spindle and the subsequent segregation of sister chromatids are based on the self-organized action of microtubule filaments, motor proteins, and other microtubule-associated proteins, which constitute the fundamental force-generating elements in the system. Many of the components in the spindle have been identified, but until recently it remained unclear how their collective behaviors resulted in such a robust bipolar structure. Here, we review the current understanding of the physics of the metaphase spindle that is only now starting to emerge.