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Journal Article

The impact of the glial spatial buffering on the K+ Nernst potential

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Noori, H. (2011). The impact of the glial spatial buffering on the K+ Nernst potential. Cognitive Neurodynamics, 5(3), 285-291. doi:10.1007/s11571-011-9165-x.

Cite as: https://hdl.handle.net/21.11116/0000-0001-B1E9-0
Astrocytes play a critical role in CNS metabolism, regulation of volume and ion homeostasis of the interstitial space. Of special relevance is their clearance of K+ that is released by active neurons into the extracellular space. Mathematical analysis of a modified Nernst equation for the electrochemical equilibrium of neuronal plasma membranes, suggests that K+ uptake by glial cells is not only relevant during neuronal activity but also has a non-neglectable impact on the basic electrical membrane properties, specifically the resting membrane potential, of neurons and might be clinically valuable as a factor in the genetics and epigenetics of the epilepsy and tuberous sclerosis complex.