User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse




Journal Article

Apicobasal polarity of brain endothelial cells


Worzfeld,  Thomas
Pharmacology, Max Planck Institute for Heart and Lung Research, Max Planck Society;

There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available

Worzfeld, T., & Schwaninger, M. (2016). Apicobasal polarity of brain endothelial cells. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36(2), 340-362. doi:10.1177/0271678X15608644.

Cite as: http://hdl.handle.net/21.11116/0000-0001-BFD8-5
Normal brain homeostasis depends on the integrity of the blood-brain barrier that controls the access of nutrients, humoral factors, and immune cells to the CNS. The blood-brain barrier is composed mainly of brain endothelial cells. Forming the interface between two compartments, they are highly polarized. Apical/luminal and basolateral/abluminal membranes differ in their lipid and (glyco-) protein composition, allowing brain endothelial cells to secrete or transport soluble factors in a polarized manner and to maintain blood flow. Here, we summarize the basic concepts of apicobasal cell polarity in brain endothelial cells. To address potential molecular mechanisms underlying apicobasal polarity in brain endothelial cells, we draw on investigations in epithelial cells and discuss how polarity may go awry in neurological diseases.