Organ Function as a Modulator of Organ Formation: Lessons from Zebrafish

Collins, Michelle M.; Stainier, Didier Y.R.

doi:10.1016/bs.ctdb.2015.10.017

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Organ Function as a Modulator of Organ Formation: Lessons from Zebrafish

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Collins, Michelle M.
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;

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Stainier, Didier Y.R.
Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society;

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Collins, M. M., & Stainier, D. Y. (2016). Organ Function as a Modulator of Organ Formation: Lessons from Zebrafish. ESSAYS ON DEVELOPMENTAL BIOLOGY, PT B, 417-433. doi:10.1016/bs.ctdb.2015.10.017.

Cite as: https://hdl.handle.net/21.11116/0000-0001-BF85-2

Abstract

Organogenesis requires an intricate balance between cell differentiation and tissue growth to generate a complex and fully functional organ. However, organogenesis is not solely driven by genetic inputs, as the development of several organ systems requires their own functionality. This theme is particularly evident in the developing heart as progression of cardiac development is accompanied by increased and altered hemodynamic forces. In the absence or disruption of these forces, heart development is abnormal, suggesting that the heart must sense these changes and respond appropriately. Here, we discuss concepts of how embryonic heart function contributes to heart development using lessons learned mostly from studies in zebrafish.