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Journal Article

Semaphorins and Plexins in Kidney Disease


Worzfeld,  Thomas
Pharmacology, Max Planck Institute for Heart and Lung Research, Max Planck Society;

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Xia, J., & Worzfeld, T. (2016). Semaphorins and Plexins in Kidney Disease. NEPHRON, 132(2), 93-100. doi:10.1159/000443645.

Cite as: https://hdl.handle.net/21.11116/0000-0001-BF81-6
Semaphorins are soluble or membrane-bound cues, which control multiple aspects of cell-cell communication, differentiation, morphology and function. Most of their effects are mediated by a family of transmembrane receptors called plexins. Semaphorins and plexins have emerged as central regulators of diverse physiological and pathophysiological processes in various organs. This review summarizes the role of semaphorins and plexins in renal pathophysiology and their potential use as biomarkers of kidney disease. (C) 2016 S. Karger AG, Basel