Correlations in Scattered X-Ray Laser Pulses Reveal Nanoscale Structural 
Features of Viruses

Kurta, R. P.; Donatelli, J. J.; Yoon, C. H.; Berntsen, P.; Bielecki, J.; Daurer, B. J.; DeMirci, H.; Fromme, P.; Hantke, M. F.; Maia, F. R. N. C.; Munke, A.; Nettelblad, C.; Pande, K.; Reddy, H. K. N.; Sellberg, J. A.; Sierra, R. G.; Svenda, M.; van der Schot, G.; Vartanyants, I. A.; Williams, G. J.; Paulraj, L. X.; Aquila, A.; Zwart, P. H.; Mancuso, A. P.

doi:10.1103/PhysRevLett.119.158102

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Correlations in Scattered X-Ray Laser Pulses Reveal Nanoscale Structural Features of Viruses

MPS-Authors

/persons/resource/persons194656

Paulraj, L. X.
International Max Planck Research School for Ultrafast Imaging & Structural Dynamics (IMPRS-UFAST), Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society;
Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY;

External Resource

https://dx.doi.org/10.1103/PhysRevLett.119.158102
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

PhysRevLett.119.158102.pdf
(Publisher version), 5MB

Supplementary Material (public)

suppl.zip
(Supplementary material), 42MB

Citation

Kurta, R. P., Donatelli, J. J., Yoon, C. H., Berntsen, P., Bielecki, J., Daurer, B. J., et al. (2017). Correlations in Scattered X-Ray Laser Pulses Reveal Nanoscale Structural Features of Viruses. Physical Review Letters, 119(15): 158102. doi:10.1103/PhysRevLett.119.158102.

Cite as: https://hdl.handle.net/21.11116/0000-0001-C0F4-2

Abstract

We use extremely bright and ultrashort pulses from an x-ray free-electron laser (XFEL) to measure correlations in x rays scattered from individual bioparticles. This allows us to go beyond the traditional crystallography and single-particle imaging approaches for structure investigations. We employ angular correlations to recover the three-dimensional (3D) structure of nanoscale viruses from x-ray diffraction data measured at the Linac Coherent Light Source. Correlations provide us with a comprehensive structural fingerprint of a 3D virus, which we use both for model-based and ab initio structure recovery. The analyses reveal a clear indication that the structure of the viruses deviates from the expected perfect icosahedral symmetry. Our results anticipate exciting opportunities for XFEL studies of the structure and dynamics of nanoscale objects by means of angular correlations.