Unraveling the Complex Interplay Between T Cell Metabolism and Function

Klein-Geltink, Ramon; Kyle, Ryan L.; Pearce, Erika L.

doi:10.1146/annurev-immunol-042617-053019

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Unraveling the Complex Interplay Between T Cell Metabolism and Function

MPS-Authors

/persons/resource/persons201360

Klein-Geltink, Ramon
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Kyle, Ryan L.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons201431

Pearce, Erika L.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

External Resource

https://www.annualreviews.org/doi/full/10.1146/annurev-immunol-042617-053019?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Klein-Geltink, R., Kyle, R. L., & Pearce, E. L. (2018). Unraveling the Complex Interplay Between T Cell Metabolism and Function. Annual Review of Immunology, 36, 461-488. doi:10.1146/annurev-immunol-042617-053019.

Cite as: https://hdl.handle.net/21.11116/0000-0001-F66E-F

Abstract

Metabolism drives function, on both an organismal and a cellular level. In T cell biology, metabolic remodeling is intrinsically linked to cellular development, activation, function, differentiation, and survival. After naive T cells are activated, increased demands for metabolic currency in the form of ATP, as well as biomass for cell growth, proliferation, and the production of effector molecules, are met by rewiring cellular metabolism. Consequently, pharmacological strategies are being developed to perturb or enhance selective metabolic processes that are skewed in immune-related pathologies. Here we review the most recent advances describing the metabolic changes that occur during the T cell lifecycle. We discuss how T cell metabolism can have profound effects on health and disease and where it might be a promising target to treat a variety of pathologies.