Is the ferric hydroperoxy species responsible for sulfur oxidation in 
cytochrome p450s?

Cryle, Max; De Voss, James J.

doi:10.1002/anie.200603411

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Is the ferric hydroperoxy species responsible for sulfur oxidation in cytochrome p450s?

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Cryle, Max
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Cryle, M., & De Voss, J. J. (2006). Is the ferric hydroperoxy species responsible for sulfur oxidation in cytochrome p450s? Angewandte Chemie International Edition, 45(48), 8221-8223. doi:10.1002/anie.200603411.

Cite as: https://hdl.handle.net/21.11116/0000-0001-DCCB-3

Abstract

Not the ferryl oxidant? The oxidation of thiafatty acids by P450BM3 (CYP102A1) was shown to be consistent with oxidation by the ferric hydroperoxy species (Cpd 0) rather than the expected ferryl species (Cpd 1). This is the first indication that sulfur oxidation in a wildtype P450 occurs via the hydroperoxy species.