Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Neurog3 misexpression unravels mouse pancreatic ductal cell plasticity


Mansouri,  A.
Research Group of Molecular Cell Differentiation, MPI for biophysical chemistry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

(Publisher version), 37MB

Supplementary Material (public)
There is no public supplementary material available

Vieira, A., Vergoni, B., Courtney, M., Druelle, N., Gjernes, E., Hadzic, B., et al. (2018). Neurog3 misexpression unravels mouse pancreatic ductal cell plasticity. PLoS One, 13(8): e0201536. doi:10.1371/journal.pone.0201536.

Cite as: https://hdl.handle.net/21.11116/0000-0001-EA72-7
In the context of type 1 diabetes research and the development of insulin-producing β-cell replacement strategies, whether pancreatic ductal cells retain their developmental capability to adopt an endocrine cell identity remains debated, most likely due to the diversity of models employed to induce pancreatic regeneration. In this work, rather than injuring the pancreas, we developed a mouse model allowing the inducible misexpression of the proendocrine gene Neurog3 in ductal cells in vivo. These animals developed a progressive islet hypertrophy attributed to a proportional increase in all endocrine cell populations. Lineage tracing experiments indicated a continuous neo-generation of endocrine cells exhibiting a ductal ontogeny. Interestingly, the resulting supplementary β-like cells were found to be functional. Based on these findings, we suggest that ductal cells could represent a renewable source of new β-like cells and that strategies aiming at controlling the expression of Neurog3, or of its molecular targets/co-factors, may pave new avenues for the improved treatments of diabetes.