English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Harmonic brain modes: A unifying framework for linking space and time in brain dynamics

MPS-Authors
/persons/resource/persons208989

Deco,  Gustavo
Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain;
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain;
School of Psychological Sciences, Monash University, Melbourne, Australia;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Atasoy, S., Deco, G., Kringelbach, M. L., & Pearson, J. (2018). Harmonic brain modes: A unifying framework for linking space and time in brain dynamics. The Neuroscientist, 24(3), 277-293. doi:10.1177/1073858417728032.


Cite as: https://hdl.handle.net/21.11116/0000-0001-F6E6-6
Abstract
A fundamental characteristic of spontaneous brain activity is coherent oscillations covering a wide range of frequencies. Interestingly, these temporal oscillations are highly correlated among spatially distributed cortical areas forming structured correlation patterns known as the resting state networks, although the brain is never truly at “rest.” Here, we introduce the concept of harmonic brain modes—fundamental building blocks of complex spatiotemporal patterns of neural activity. We define these elementary harmonic brain modes as harmonic modes of structural connectivity; that is, connectome harmonics, yielding fully synchronous neural activity patterns with different frequency oscillations emerging on and constrained by the particular structure of the brain. Hence, this particular definition implicitly links the hitherto poorly understood dimensions of space and time in brain dynamics and its underlying anatomy. Further we show how harmonic brain modes can explain the relationship between neurophysiological, temporal, and network-level changes in the brain across different mental states (wakefulness, sleep, anesthesia, psychedelic). Notably, when decoded as activation of connectome harmonics, spatial and temporal characteristics of neural activity naturally emerge from the interplay between excitation and inhibition and this critical relation fits the spatial, temporal, and neurophysiological changes associated with different mental states. Thus, the introduced framework of harmonic brain modes not only establishes a relation between the spatial structure of correlation patterns and temporal oscillations (linking space and time in brain dynamics), but also enables a new dimension of tools for understanding fundamental principles underlying brain dynamics in different states of consciousness.