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Trade-off of cerebello-cortical and cortico-cortical functional networks for planning in 6-year-old children

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Margulies,  Daniel S.
Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Kipping, J. A., Margulies, D. S., Eickhoff, S. B., Lee, A., & Qiu, A. (2018). Trade-off of cerebello-cortical and cortico-cortical functional networks for planning in 6-year-old children. NeuroImage, 176, 510-517. doi:10.1016/j.neuroimage.2018.04.067.


Cite as: http://hdl.handle.net/21.11116/0000-0001-F6B4-E
Abstract
Childhood is a critical period for the development of cognitive planning. There is a lack of knowledge on its neural mechanisms in children. This study aimed to examine cerebello-cortical and cortico-cortical functional connectivity in association with planning skills in 6-year-olds (n = 76). We identified the cerebello-cortical and cortico-cortical functional networks related to cognitive planning using activation likelihood estimation (ALE) meta-analysis on existing functional imaging studies on spatial planning, and data-driven independent component analysis (ICA) of children's resting-state functional MRI (rs-fMRI). We investigated associations of cerebello-cortical and cortico-cortical functional connectivity with planning ability in 6-year-olds, as assessed using the Stockings of Cambridge task. Long-range functional connectivity of two cerebellar networks (lobules VI and lateral VIIa) with the prefrontal and premotor cortex were greater in children with poorer planning ability. In contrast, cortico-cortical association networks were not associated with the performance of planning in children. These results highlighted the key contribution of the lateral cerebello-frontal functional connectivity, but not cortico-cortical association functional connectivity, for planning ability in 6-year-olds. Our results suggested that brain adaptation to the acquisition of planning ability during childhood is partially achieved through the engagement of the cerebello-cortical functional connectivity.