Mille viae in eukaryotic mRNA decapping

Valkov, E; Jonas, S; Weichenrieder, O

doi:10.1016/j.sbi.2017.05.009

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Mille viae in eukaryotic mRNA decapping

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Valkov, E
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

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Weichenrieder, O
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;
Retrotransposition and Regulatory RNAs Group, Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

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Valkov, E., Jonas, S., & Weichenrieder, O. (2017). Mille viae in eukaryotic mRNA decapping. Current Opinion in Structural Biology, 47, 40-51. doi:10.1016/j.sbi.2017.05.009.

Cite as: https://hdl.handle.net/21.11116/0000-0002-1370-A

Abstract

Cellular mRNA levels are regulated via rates of transcription and decay. Since the removal of the mRNA 5'-cap by the decapping enzyme DCP2 is generally an irreversible step towards decay, it requires regulation. Control of DCP2 activity is likely effected by two interdependent means: by conformational control of the DCP2-DCP1 complex, and by assembly control of the decapping network, an array of mutually interacting effector proteins. Here, we compare three recent and conformationally distinct crystal structures of the DCP2-DCP1 decapping complex in the presence of substrate analogs and decapping enhancers and we discuss alternative substrate recognition modes for the catalytic domain of DCP2. Together with structure-based insight into decapping network assembly, we propose that DCP2-mediated decapping follows more than one path.