Functional and Structural Roles of Coiled Coils

Hartmann, MD

doi:10.1007/978-3-319-49674-0_3

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Functional and Structural Roles of Coiled Coils

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Hartmann, MD
Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society;
Molecular Recognition and Catalysis Group, Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Citation

Hartmann, M. (2017). Functional and Structural Roles of Coiled Coils. In D. Parry, & J. Squire (Eds.), Fibrous Proteins: Structures and Mechanisms (pp. 63-93). Cham, Switzerland: Springer. doi:10.1007/978-3-319-49674-0_3.

Cite as: https://hdl.handle.net/21.11116/0000-0002-038C-D

Abstract

Coiled coils appear in countless structural contexts, as appendages to small proteins, as parts of multi-domain proteins, and as building blocks of filaments. Although their structure is unpretentious and their basic properties are understood in great detail, the spectrum of functional properties they provide in different proteins has become increasingly complex. This chapter aims to depict this functional spectrum, to identify common themes and their molecular basis, with an emphasis on new insights gained into dynamic aspects.