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Journal Article

Microbiome and metabolic disease: revisiting the bacterial phylum Bacteroidetes

MPS-Authors

Walters,  William A.
Max Planck Institute for Developmental Biology, Max Planck Society;

Ley,  Ruth E.
Department of Molecular Biology and Genetics, Cornell University, Ithaca;
Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Johnson, E. L., Heaver, S. L., Walters, W. A., & Ley, R. E. (2017). Microbiome and metabolic disease: revisiting the bacterial phylum Bacteroidetes. Journal of Molecular Medicine, 95(1), 1-8. doi:10.1007/s00109-016-1492-2.


Cite as: http://hdl.handle.net/21.11116/0000-0002-130F-9
Abstract
Bacterial species composition in the gut has emerged as an important factor in obesity and its related metabolic diseases such as type 2 diabetes. Out of thousands of bacterial species level phylotypes inhabiting the human gut, the majoiity belong to two dominant phyla, the Bacteroidetes and Firmicutes. Members of the Bacteroidetes in particular have been associated with human metabolic diseases. However, their associations with disease are not always consistent between studies. Delving deeper into the diversity within the Bacteroidetes reveals a vast diversity in genomes and capacities, which partly explain how not all members respond equally to similar environmental conditions in their hosts. Here, we discuss the Bacteroidetes phylum, associations of its members with metabolic phenotypes, and efforts to characterize functionally their interactions with their hosts. Harnessing the Bacteroidetes to promote metabolic health will require a nuanced understanding of how specific strains interact with their microbial neighbors and their hosts under various conditions.