Mechanistic Studies of the Cu(OH)+‐Catalyzed Isomerization of Glucose into 
Fructose in Water

Mensah, Joel B.; Delidovich, Irina; Hausoul, Peter J. C.; Weisgerber, Laurent; Schrader, Wolfgang; Palkovits, Regina

doi:10.1002/cssc.201800483

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Mechanistic Studies of the Cu(OH)⁺‐Catalyzed Isomerization of Glucose into Fructose in Water

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Schrader, Wolfgang
Service Department Schrader (MS), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Mensah, J. B., Delidovich, I., Hausoul, P. J. C., Weisgerber, L., Schrader, W., & Palkovits, R. (2018). Mechanistic Studies of the Cu(OH)⁺‐Catalyzed Isomerization of Glucose into Fructose in Water. ChemSusChem, 11(15), 2579-2586. doi:10.1002/cssc.201800483.

Cite as: https://hdl.handle.net/21.11116/0000-0002-4571-1

Abstract

The isomerization of glucose to fructose is a crucial interim step in the processing of biomass to renewable fuels and chemicals. This study investigates the copper‐catalyzed glucose–fructose isomerization in water, focusing on insights into the roles of the dissolved copper species. Depending on the pH, the thermodynamic equilibrium shifted towards one or a few copper species, namely Cu²⁺, Cu(OH)⁺, and Cu(OH)₂. According to thermodynamics, the highest concentration of Cu(OH)⁺ is at pH 5.3, at which the highest fructose yield of 16 % is achieved. The obtained fructose yields strongly correlate with the concentration of Cu(OH)⁺. A pH decrease of 2–3 units was observed during the reaction, resulting in the deactivation of the catalyst through hydrolysis in acidic media. Based on the results of the catalytic experiments, as well as spectroscopic and spectrometric studies, we propose Cu(OH)⁺ as an active Lewis‐acidic species following an intramolecular 1,2‐hydride shift.